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    Doxycycline-d 3 is intended for use as an internal standard for the quantification of doxycycline (Item No. 14422) by GC- or LC-MS. Doxycycline is a broad-spectrum tetracycline antibiotic. 1,2 It inhibits bacterial protein synthesis by binding to ribosomes. 2,3 Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition ...

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    Acknowledgements: The EMA CVMP and the EFSA BIOHAZ Panel wish to thank the following for the support provided to this scientific opinion: the EFSA Panel on Animal Health and Welfare (AHAW), which endorsed Section 4.2 of the scientific opinion; the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), which endorsed Section 4.4 of the scientific opinion; the EMA ...

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